
Unlock the Potential of Gelatin
Nitta’s low endotoxin gelatin and collagen “beMatrix” were developed as a versatile solution to many challenges in the development of medical devices and therapeutics. Unlock the Potential of beMatrixFeatured Applications
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Virus Stabilization

Local Injection

Controlled Release of Growth Factors

Cell/Tissue Transportation
Virus Stabilization

Problem

Solution
Example (Oncolytic Virus)
Step 1: Mix the oncolytic virus with “beMatrix biotech+ virus stabilization”
Step 2: Shipping the product by 4℃
Step 3: Administration of oncolytic virus
Reference:
1. Kadji et al. ;Stability of enveloped and nonenveloped viruses in hydrolyzed gelatin liquid formulation. Virology Journal 19:94 (2022)
Local Injection

Problem
Precision is a challenge when administering therapeutics via Local Injection. Costly biologics are lost to leakage from the injection site and inaccurate administration decreases the efficacy of a payload.

Solution
beMatrix biotech+ for Local Injection can reduce seepage from a needle’s entry point and improve the efficiency, accuracy, and suspension of administered therapies at your intended injection target.
Example (Cell & Gene Therapy)
Step 1: Mix the injectable drug with “beMatrix biotech+ for Local Injection”
Step 2: Inject into the target site
Step 3: Reduced seepage
Step 4: Expensive drugs can be used more efficiently.
Prevent of complications due to leakage.
Reference:
1. Anamizu.M et al.; Acta Biomaterialia, 100:184-190
2. Kotani.K et al.; under preparation
Controlled Release of Growth Factors

Problem

Solution
Application
Limb ischemia (Angiogenesis), Sudden hearing loss, Facial nerve paralysis, Femoral head necrosis, Heart failure (Angiogenesis), Induced avascular necrosis of the jaws.
Example (Regenerative Medicine)
Step 2: Administer to the defect site
Step 3: Slow release of growth factors at the site
Step 4: Promotes regeneration of defect sites
Reference:
1) Femoral head necrosis
-Kuroda.Y et al; Int Orthop. 2016 Aug;40(8):1747-1754.
‐Kuroda.Y et al; Regen Med. 2021 Jun;16(6):535-548.
2) limb ischemia
-Kumagai.M et al; Heart Vessels. 2016 May;31(5):713-21.
3) Sudden hearing loss
-Nakagawa.T et al; BMC Med. 2010 Nov 25;8:76.
4) Facial nerve paralysis
-Hata.N et al; Otolaryngol Head Neck Surg. 2012 Apr;146(4):641-6.
Cell / Tissue Transportation

Problem
When transporting cell sheets, spheroids, and 3D structures using cells (cell tubes, etc.), there are problems such as deformation and cell necrosis. These are very time-consuming and costly to manufacture, so care must be taken in transporting them until they are used for transplantation.

Solution
Example
Step 2: Once the “beMatrix biotech+ Cell / Tissue Transportation” has gelled and the tissue has been fixed, it is transported to its destination.
Step 3: Dissolve the gel on site and remove the tissue.
Step 4: Transplant surgery to the patient.
Reference:
1. Ohyabu.Y et al; J Biosci Bioeng. 2014 Jul;118(1):112-5.
Other Applications
Biotech
- Local injection
- Virus stabilization
- Controlled release of drug
- Cell tissue transportation
Medical Device
- Bone void filler
- Arterial Embolization
- Hemostatic agent
- Coating
- Adhesive
- Wound dressing
- Artificial nerve and other tissue
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Unlock the potential of gelatin.